Welcome to PlewkaLAB!
At PlewkaLAB, we focus on the development of innovative inhibitor classes targeting LAG-3/ligand interactions. Our workflow integrates multiple approaches:
- Discovery
Screening novel compounds through both virtual platforms and in-house chemical libraries.
- Design
Leveraging molecular docking and molecular dynamics to guide compound optimization.
- Validation
Confirming hits with a range of biochemical (HTRF, MST, nanoDSF, DLS) and biological (MTT, immunoassay, cytokine release) assays.
- Structural insights
Expressing, purifying, and crystallizing proteins of interest to deepen understanding of their structure, mechanism of action, and interactions with ligands and inhibitors.
Our expertise covers small molecule inhibitors (competitive and covalent), peptides, and aptamers.
We are eager to collaborate with:
- Research teams...
working on other protein targets, offering our expertise in hit validation, assay development, and structural biology.
- Chemists...
with unique libraries, to explore novel compounds against our protein targets.